解决MAC上R语言monocle3的错误“function ‘as_cholmod_sparse‘ not provided by package ‘Matrix‘”

Error in (function (A, nv = 5, nu = nv, maxit = 1000, work = nv + 7, reorth = TRUE, : function ‘as_cholmod_sparse’ not provided by package ‘Matrix’

根据这个issue(https://github.com/cole-trapnell-lab/monocle3/issues/690 )所说，解决方法是重新编译安装两个库，命令如下：

remove.packages("Matrix")
remove.packages("irlba")
install.packages("Matrix",type="source", dependencies=T)
install.packages("irlba",type="source", dependencies=T)

当我编译时，遇到了gfortran链接错误

library not found for lgfortran

我手动从GitHub 安装了gfortrain for mac， 也设置了软链接：

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ln -s /usr/local/gfortran /opt/gfortran

之后按照文档 中所述在~/.R/Makevar中设置了相应路径的链接标志如下所示。

FLIBS = -L/opt/gfortran/lib/gcc/aarch64-apple-darwin23/13.2.0 -L/opt/gfortran/lib -lgfortran -lemutls_w -lquadmat

然后重新编译即可。